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Drapc1 expression during mouse embryonic development.

Tomi Jukkola1, Natalia Sinjushina, Juha Partanen

  • 1Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, P.O. Box 56, Viikinkaari 9, University of Helsinki, Helsinki 00014, Finland.

Gene Expression Patterns : GEP
|October 7, 2004
PubMed
Summary
This summary is machine-generated.

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Researchers identified the mouse APCDD1 gene, a Wnt/beta-catenin signaling target. Its expression in developing mouse embryos and adult skin suggests a role in embryonic development and tissue homeostasis.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Genetics

Background:

  • The Wnt/beta-catenin signaling pathway plays a crucial role in embryonic development and cancer.
  • Identifying novel target genes of this pathway is essential for understanding its functions.
  • The human gene DRAPC1 (also known as APCDD1) is implicated in cellular processes.

Purpose of the Study:

  • To identify and characterize the mouse homolog of the human DRAPC1 (APCDD1) gene.
  • To investigate the spatiotemporal expression pattern of mouse Drapc1 during embryonic development.
  • To determine if mouse Drapc1 is a target gene of the Wnt/beta-catenin signaling pathway in vivo.

Main Methods:

  • Gene identification and characterization.
  • Analysis of gene expression in mouse embryos (E7.5-E14) using techniques like in situ hybridization (implied).

Related Experiment Videos

  • Comparison of Drapc1 expression patterns with known Wnt/beta-catenin signaling activity in developing embryos.

    • Main Results:

    • The mouse homolog of human DRAPC1 (APCDD1) was identified.
    • Drapc1 exhibits specific expression patterns during mouse embryonic development, including extraembryonic structures, nervous system, vascular system, and inner ear.
    • Expression was observed in mesenchymal cells at sites of epithelial-mesenchymal interactions and in adult hair follicles.
    • The expression pattern of Drapc1 correlates with the localization of active beta-catenin in developing embryos.

    Conclusions:

    • Mouse Drapc1 is a novel in vivo target gene of the Wnt/beta-catenin signaling pathway.
    • Drapc1 expression during embryogenesis suggests its involvement in the development of various tissues and organs.
    • The gene's presence in adult hair follicles indicates potential roles in adult tissue homeostasis or regeneration.