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Related Experiment Videos

Stress causes a further decrease in immunity to herpes simplex virus-1 in immunocompromised hosts.

Ling Cao1, Amy Martin, Noelle Polakos

  • 1Department of Psychiatry, The Center for Psychoneuroimmunology, University of Rochester, Rochester, NY 14642, USA. Ling_Cao@urmc.rochester.edu

Journal of Neuroimmunology
|October 7, 2004
PubMed
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Physical or psychological stress exacerbates immunosuppression in mice infected with herpes simplex virus-1 (HSV-1) and treated with cyclophosphamide (CY). Stress further reduced immune responses, highlighting the need to consider patient stress levels during immunosuppressive therapy.

Area of Science:

  • Immunology
  • Virology
  • Stress Physiology

Background:

  • Physical or psychological stress impacts immune responses in healthy individuals.
  • The effect of stress on immunity in immunocompromised hosts remains under-investigated.

Purpose of the Study:

  • To assess the combined effects of footshock stress (FS), herpes simplex virus-1 (HSV-1) infection, and cyclophosphamide (CY) immunosuppression on immune responses in BALB/c mice.

Main Methods:

  • Mice were subjected to HSV-1 infection and treated with CY, with or without FS.
  • Evaluated host survival, body weight, leukocyte counts, cytokine levels (in vivo and in vitro), and antibody secretion.
  • Assessed numbers of IL-12 and IFN-gamma producing cells.

Main Results:

Related Experiment Videos

  • CY significantly impaired anti-HSV-1 immunity, reducing survival, leukocyte numbers, and cytokine production.
  • FS alone inhibited cell-mediated anti-viral responses.
  • Combined FS and CY treatment resulted in significantly worse outcomes than either treatment alone, including reduced survival and cytokine production.

Conclusions:

  • Stress can further compromise immune function in immunocompromised individuals.
  • Patient stress levels should be considered before initiating immunosuppressive treatments.