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L-arginine and hypertension.

Noyan Gokce1

  • 1Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA. Noyan.Gokce@bmc.org

The Journal of Nutrition
|October 7, 2004
PubMed
Summary

L-arginine supplementation may improve endothelial function and blood pressure in hypertension by enhancing nitric oxide production. Further clinical studies are needed to confirm its therapeutic role.

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Hypertension affects millions, with many patients uncontrolled, increasing cardiovascular disease risk.
  • Endothelial dysfunction and reduced nitric oxide (NO) bioactivity are key in hypertension.
  • Prevalence is rising due to aging, obesity, and metabolic syndrome.

Purpose of the Study:

  • To review the potential role of L-arginine in managing hypertension.
  • To explore mechanisms of L-arginine action in hypertensive cardiovascular disease.
  • To assess L-arginine's impact on nitric oxide production and endothelial function.

Main Methods:

  • Review of existing studies on L-arginine supplementation in hypertension.
  • Analysis of L-arginine's role in nitric oxide (NO) production.
  • Examination of L-arginine's effect on endothelial dysfunction and vascular tone.

Main Results:

  • L-arginine is the substrate for vascular NO production.
  • Studies suggest L-arginine supplementation may improve endothelial function and NO bioactivity.
  • Some evidence indicates L-arginine can reduce blood pressure in experimental hypertension.

Conclusions:

  • L-arginine may modulate NO production and improve endothelial function in hypertension.
  • Altering the asymmetrical dimethylarginine (ADMA):L-arginine balance is a potential mechanism.
  • Further randomized clinical trials are warranted to establish L-arginine's therapeutic efficacy.

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