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Related Experiment Video

Updated: Feb 8, 2026

Detection of Abnormal Prion Protein by Immunohistochemistry

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

Sonographic detection of the normal and abnormal appendix.

¹Department of Radiology, Hôpital Saint-François d'Assise, Québec, Canada.

AJR. American Journal of Roentgenology

|April 1, 1992

Summary

This summary is machine-generated.

Ultrasound (sonography) effectively detects appendicitis, accurately identifying normal appendices in 82% of cases. This imaging technique offers high sensitivity (93%) and specificity (94%) for diagnosing appendicitis, including ruptured cases.

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Area of Science:

Medical Imaging
Gastroenterology
Emergency Medicine

Background:

Appendicitis diagnosis can be challenging, necessitating accurate imaging modalities.
Sonography is a non-invasive tool increasingly used for abdominal pain evaluation.

Purpose of the Study:

To evaluate the diagnostic value of sonography in identifying normal and abnormal appendices.
To determine the sensitivity, specificity, and accuracy of ultrasound in diagnosing appendicitis.

Main Methods:

Prospective study of 170 patients with suspected appendicitis.
Primary sonographic criteria included wall thickness (≤3 mm), compressibility, and periappendiceal fat echogenicity.
Surgical confirmation or clinical follow-up was used to establish the final diagnosis.

Main Results:

Sonography identified a normal appendix in 102 (82%) of 125 patients without appendicitis.
Sensitivity for appendicitis was 93%, specificity 94%, and accuracy 94%.
Positive predictive value was 86%, negative predictive value 98%; all 11 ruptured appendicitis cases were correctly predicted.

Conclusions:

Sonography is a valuable tool for diagnosing acute appendicitis.
Ultrasound can visualize the normal appendix more frequently than previously reported, aiding in differential diagnosis.