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A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Habitual snoring, intermittent hypoxia, and impaired behavior in primary school children
Michael S Urschitz1, Steffen Eitner, Anke Guenther
1Department of Neonatology, University Children's Hospital, Tuebingen, Germany.
Insights
Habitual snoring in children is linked to behavioral issues, independent of intermittent hypoxia. These behavioral problems improve when snoring stops, suggesting a direct link between snoring cessation and better behavior.
Area of Science:
- Pediatric Sleep Medicine
- Child Psychology
- Respiratory Medicine
Background:
- Sleep-disordered breathing, including habitual snoring, is a known risk factor for behavioral and academic deficits in children.
- The specific impact of habitual snoring and the role of intermittent hypoxia on these deficits require further clarification.
Purpose of the Study:
- To assess behavioral problems in children with habitual snoring (HS).
- To investigate the influence of intermittent hypoxia on these behaviors.
- To evaluate the reversibility of behavioral and academic impairments after cessation of HS.
Main Methods:
- 1144 children were assessed for habitual snoring and behavioral issues via parental questionnaires.
- Intermittent hypoxia was measured using pulse oximetry.
- Academic performance was evaluated using school reports; all factors were reassessed after one year.
Main Results:
- Habitual snoring was significantly associated with hyperactivity, inattention, daytime tiredness, sleepiness, conduct problems, emotional symptoms, and peer issues.
- These associations persisted independently of intermittent hypoxia.
- Hyperactive and inattentive behaviors improved significantly after HS ceased, while academic performance did not show similar improvement.
Conclusions:
- Impaired behavior is a primary characteristic of habitual snoring in children, separate from intermittent hypoxia.
- Behavioral improvements are observed when habitual snoring is no longer present.
Objectives:
Sleep-disordered breathing is associated with impaired behavior and poor academic performance in children. We aimed to determine the extent of behavioral problems in snoring children, clarify the role of intermittent hypoxia, and test the reversibility of impaired behavior and poor academic performance.
Methods:
In 1144 children, habitual snoring (HS; snoring frequently or always) and impaired behavior were assessed using parental questionnaires. Intermittent hypoxia (ie, presence of > or =5 arterial oxygen desaturations by > or =4% or > or =1 desaturation to < or =90%) was investigated with pulse oximetry. Poor academic performance (grade 4-6 on a 6-point scale in mathematics, science, or spelling) was based on the last school report. HS, impaired behavior, and academic performance were reevaluated after 1 year. Adjusted odds ratios (ORs) were calculated using unconditional logistic regression.
Results:
HS was significantly associated with hyperactive (OR: 2.4) and inattentive behavior (OR: 4.0), daytime tiredness (OR: 7.1), and sleepiness (OR: 2.6-4.8). These associations were independent of intermittent hypoxia. HS was also significantly associated with bad conduct (OR: 2.8), emotional symptoms (OR: 5.5), and peer problems (OR: 9.7). At follow-up, hyperactive and inattentive behavior but not academic success had significantly improved in children in whom HS had ceased.
Conclusions:
We suggest that impaired behavior is a key feature of HS independent of intermittent hypoxia and improves when HS ceases.
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