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Primary pulmonary non-Hodgkin's lymphoma
Jung Han Kim1, Se-Hoon Lee, Jinny Park
1Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710 Seoul, Korea.
Japanese Journal of Clinical Oncology
|October 7, 2004
Summary
Primary pulmonary non-Hodgkin's lymphoma, most commonly MALT lymphoma, presents varied symptoms and radiological findings. This rare lymphoma shows an 86% 3-year survival rate, indicating a good prognosis.
Area of Science:
- Oncology
- Pulmonary Medicine
- Hematology
Background:
- Primary pulmonary non-Hodgkin's lymphoma is a rare malignancy.
- Marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type is the most common subtype.
- Clinical features, diagnosis, management, and prognostic factors require further definition.
Purpose of the Study:
- To review the clinical characteristics, diagnostic methods, treatment approaches, and outcomes of primary pulmonary lymphoma.
- To evaluate the prognostic factors and survival rates in patients with primary pulmonary lymphoma.
Main Methods:
- Retrospective review of medical records for 24 patients diagnosed with primary pulmonary lymphoma between September 1995 and June 2003.
- Analysis of clinical presentation, radiological findings, diagnostic procedures (including bronchoscopy and surgery), treatment modalities, and survival data.
Main Results:
- MALT lymphoma was the most frequent type (13 patients), with other subtypes including diffuse large B-cell lymphoma and anaplastic large cell lymphoma.
- Half of the patients were asymptomatic; respiratory or B-symptoms were present in 46% and 16.7%, respectively.
- Surgical approaches were necessary for diagnosis in 66.7% of cases, while bronchoscopy had a 30% diagnostic yield. The 3-year overall survival rate was 86%.
Conclusions:
- Primary pulmonary lymphoma, particularly MALT type, appears to have a favorable prognosis.
- Further clinical studies and long-term follow-up are essential for identifying definitive prognostic factors and optimizing management strategies.