Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Why is revitalizing clinical research so important, yet so difficult?

Alan N Schechter1, Robert L Perlman, Richard A Rettig

  • 1Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-1822, USA. aschecht@helix.nih.gov

Perspectives in Biology and Medicine
|October 7, 2004
PubMed
Summary

Academic clinical research funding has declined due to flawed models. Rethinking conceptual frameworks for patient-oriented research is crucial for revitalization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of Cyclic Guanosine Monophosphate (cGMP) in Solid Tissues using Competitive Enzyme-Linked Immunosorbent Assay (ELISA).

Journal of visualized experiments : JoVE·2025
Same author

Nitrate as Warden of Nitric Oxide Homeostasis in Mammals.

Nutrients·2025
Same author

Sickle cell anaemia therapy in 2025.

British journal of haematology·2024
Same author

Hydroxyurea inhibits proliferation and stimulates apoptosis through inducible nitric oxide synthase in erythroid cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2024
Same author

Effects of low and high dietary nitrate intake on human saliva, plasma and skeletal muscle nitrate and nitrite concentrations and their functional consequences.

Free radical biology & medicine·2024
Same author

Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence and <sup>15</sup>N-Tracer Studies in Yorkshire Pigs.

Nutrients·2024

Area of Science:

  • Biomedical Research
  • Clinical Research
  • Medical Science

Background:

  • Academic clinical research support has significantly decreased in recent decades.
  • The shift favors basic and translational research over patient-oriented studies.
  • Current conceptual models inadequately explain medical progress.

Purpose of the Study:

  • To analyze the decline in academic clinical research.
  • To critique the prevailing "bench-to-bedside" model.
  • To propose alternative frameworks to revitalize clinical research.

Main Methods:

  • Conceptual analysis of research paradigms.
  • Historical review of medical advances.
  • Discussion of funding and organizational structures.

Related Experiment Videos

Main Results:

  • The "bench-to-bedside" model is insufficient to explain medical progress.
  • Clinical advances often drive new basic research, challenging traditional models.
  • Inappropriate conceptual paradigms contribute to the decline of clinical research.

Conclusions:

  • Revitalizing academic clinical research requires adopting new conceptual frameworks.
  • Changes in funding and organizational structures are necessary.
  • A paradigm shift is needed to better support patient-oriented research.