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Related Experiment Videos

[Mice lacking PACAP: a mini-review focussing on brain function].

Norihito Shintani1

  • 1Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan. shintani@phs.osaka-u.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|October 7, 2004
PubMed
Summary

Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) exhibit altered brain functions. These PACAP-deficient mice reveal unexpected roles for PACAP in circadian rhythms, memory, and behavior.

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Area of Science:

  • Neuroendocrinology
  • Neuroscience
  • Molecular Biology

Context:

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional peptide hormone involved in various physiological processes.
  • PACAP plays roles as a hormone, neurohormone, and neurotransmitter in both central and peripheral systems.
  • The generation of PACAP-deficient (PACAP(-/-)) mice provides a crucial model for studying endogenous PACAP functions.

Purpose:

  • To review the phenotypic changes in brain functions of PACAP(-/-) mice.
  • To elucidate the physiological roles of PACAP in the central nervous system.
  • To highlight unexpected functions of PACAP revealed through studies of knockout mice.

Summary:

  • PACAP(-/-) mice display altered light-induced phase-resetting of circadian activity rhythms.

Related Experiment Videos

  • Hippocampal long-term potentiation is affected in PACAP-deficient mice, impacting synaptic plasticity.
  • Psychomotor behaviors are modified in PACAP(-/-) mice, suggesting a role in motor control and regulation.

    • Impact:

    • Understanding PACAP's role in circadian rhythm regulation.
    • Insights into PACAP's contribution to learning and memory processes.
    • Revealing novel therapeutic targets for neurological and behavioral disorders related to PACAP signaling.