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Related Experiment Videos

Lectin-based structural glycomics: glycoproteomics and glycan profiling.

Jun Hirabayashi1

  • 1Glycostructure Analysis Team, Research Center for Gycoscience, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, 1-1-1, Higashi, Tsukuba, Ibaraki 305-8566, Japan. jun-hirabayashi@aist.go.jp

Glycoconjugate Journal
|October 7, 2004
PubMed
Summary

Structural glycomics (SG) advances functional glycomics by developing high-throughput machines for complex glycan analysis. This research focuses on glycoproteomics and lectin-based glycan profiling for comprehensive structural insights.

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Area of Science:

  • Glycobiology
  • Post-genome sciences
  • Structural glycomics

Background:

  • Structural glycomics (SG) is crucial for understanding glycan functions within glycobiology.
  • The SG project, initiated in 2003, aligns with Japan's NEDO and METI initiatives.

Purpose of the Study:

  • Develop high-throughput and robust machinery for complex glycan structural analysis.
  • Advance the field of functional glycomics through enhanced structural elucidation.

Main Methods:

  • Glycoproteomics for comprehensive glycoprotein analysis.
  • Lectin-based glycan profiling using frontal affinity chromatography.
  • Systematic analysis of lectin-oligosaccharide interactions (100x100 concept).

Main Results:

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  • Established methodologies for comprehensive glycoprotein analysis.
  • Developed a platform for large-scale glycan profiling and interaction analysis.
  • Demonstrated the utility of frontal affinity chromatography in SG.

Conclusions:

  • The SG project significantly contributes to the development of advanced glycan analysis tools.
  • High-throughput methods are essential for elucidating complex glycan structures and functions.
  • The developed techniques pave the way for deeper understanding in functional glycomics.