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Updated: Aug 14, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
Published on: July 17, 2019
Ras/Raf/ERK signalling and NF1
Marie C Harrisingh1, Alison C Lloyd
1MRC Laboratory for Molecular Cell Biology and the Department of Biochemistry, University College London, Gower Street, London, UK.
Abstract:
Ras signalling is important in the development of Schwann-cell-derived tumors in Neurofibromatosis Type 1 (NF1) patients. Schwann cells are a regenerative cell type, with no known stem-cell population. To produce new cells in the adult, for example following nerve damage, myelinating Schwann cells de-differentiate, proliferate and then re-differentiate during the repair process. We have found that Ras/Raf/ERK signalling can drive the de-differentiation of myelinated Schwann cells. In this review, we discuss how our results may contribute to the understanding of tumor formation in NF1 patients.
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