Related Experiment Video
Updated: Aug 21, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Risk of cesarean wound complications in diabetic gestations
Tamara C Takoudes1, Sherry Weitzen, Julie Slocum
1Department of Obstetrics and Gynecology, Brown University, Providence, RI, USA. tlc16@columbia.edu
Objective:
This study was undertaken to examine the association between pregestational diabetes mellitus (DM) and wound complications after cesarean delivery (CD).
Study Design:
This was a retrospective, observational cohort study in patients with type 1 and 2 DM compared with non-DM controls undergoing CD. Wound complications were defined as wound infection, wound separation greater than 1 cm, and wound dehiscence.
Results:
There was an overall incidence of wound complications of 18.4% (34/185) in DM versus 5.8% (10/174) in non-DM (unadjusted odds ratio of 3.7; 95% CI = 1.8-7.7). Mean body mass index before pregnancy was 30.9 in DM versus 26.5 kg/m 2 in non-DM (P < .01). A multivariable logistic regression model adjusting for body mass index, length of surgery, and previous CD demonstrated a 2.5-fold increased risk of wound complications in DM patients compared with non-DM patients (95% CI = 1.1-5.5).
Conclusion:
Pregestational diabetes is associated with a 2.5-fold increase in wound complications after CD.
Related Concept Videos
Complications of Diabetes Mellitus
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Type 2 and Gestational
Diabetic Retinopathy
Diabetic Foot Ulcer
Diabetes: Symptoms, Diagnosis, and Complications