Thrombophilia and pregnancy complications

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Reproductive Medicine

Background:

• Thrombophilia, a condition of increased blood clotting, is associated with adverse pregnancy outcomes.
• Gestational vascular complications, including preeclampsia and intrauterine growth restriction, pose significant risks to maternal and fetal health.

Purpose of the Study:

• To present a consensus on the implications of current data regarding the association between thrombophilia and gestational vascular complications.
• To provide recommendations for screening and management strategies for pregnant women with thrombophilia.

Main Methods:

• This report is a consensus document based on a review of available scientific literature and expert opinion.
• It synthesizes data on the link between thrombophilia and specific pregnancy complications.

Main Results:

• Screening for thrombophilia is recommended in women with a history of fetal loss (three or more first-trimester losses, two or more second-trimester losses, or stillbirth).
• Screening is also recommended for those with early, severe, or recurrent preeclampsia, and severe intrauterine growth restriction.
• Maternal antithrombotic therapy is currently being evaluated in women with thrombophilia and a history of these complications.

Conclusions:

• The findings underscore the importance of identifying thrombophilia in women with a history of specific gestational vascular complications.
• Further evaluation of maternal antithrombotic therapy is crucial for improving outcomes in this high-risk population.