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Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study.
Gili Kenet1, Dalia Waldman, Aharon Lubetsky
1The Israeli National Hemophilia Center, Sheba Medical Center, Tel-Hashomer, 52621, Israel. Gilli.kenet@sheba.health.gov.il
Thrombosis and Haemostasis
|October 7, 2004
Summary
Cerebral sinus venous thrombosis (CSVT) in children is not strongly linked to thrombophilia. However, thrombophilia screening is beneficial for children with idiopathic CSVT to guide long-term therapy decisions.
Area of Science:
- Pediatric Neurology
- Hematology
- Thrombosis Research
Background:
- Cerebral sinus venous thrombosis (CSVT) in children lacks clear understanding regarding its causes and contributing risk factors.
- The role of thrombophilic conditions in pediatric CSVT requires further investigation.
Purpose of the Study:
- To investigate the prevalence of thrombophilic risk factors in children diagnosed with CSVT.
- To compare thrombophilia markers in pediatric CSVT patients versus healthy controls.
- To assess the impact of thrombophilia on clinical presentation and treatment decisions in pediatric CSVT.
Main Methods:
- Multi-center case-controlled study involving 46 pediatric patients with CSVT and 112 healthy controls.
- Thrombophilia screening performed on all CSVT cases.
- Prospective follow-up of patients for a median of 4.1 years.
Main Results:
- No significant difference in thrombophilia marker prevalence between CSVT cases and controls.
- Co-morbid systemic illness was common in pediatric CSVT patients.
- Idiopathic CSVT cases showed a higher frequency of thrombophilic risk factors compared to those with co-morbidities.
Conclusions:
- Thrombophilia screening may benefit select pediatric patients, particularly those with idiopathic CSVT.
- Thrombophilic risk factors did not influence clinical presentation or initial treatment in this cohort.
- Further research is needed to fully elucidate the role of thrombophilia in pediatric CSVT etiology.