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Systemic thromboembolism in children. Data from the 1-800-NO-CLOTS Consultation Service

Stefan Kuhle1, Patricia Massicotte, Anthony Chan

  • 1Department of Population Health Sciences, The Hospital for Sick Children, Toronto, Canada.

Thrombosis and Haemostasis
|October 7, 2004
PubMed

Insights

Pediatric thromboembolism (TE) is common in infants, with venous TE being most frequent. Most children with TE have risk factors, especially central lines, highlighting the need for awareness and management strategies.

Area of Science:

  • Pediatric Hematology
  • Vascular Medicine
  • Clinical Pediatrics

Background:

  • Thromboembolism (TE) is increasingly recognized in pediatric populations.
  • Understanding the clinical profile of pediatric TE is crucial for effective management.
  • A large dataset from a dedicated consultation service provides insights into this condition.

Purpose of the Study:

  • To summarize the clinical characteristics of systemic thromboembolism (TE) in a large cohort of children.
  • To identify age-related differences, common locations, associated conditions, and risk factors for pediatric TE.
  • To analyze diagnostic methods and treatment variations in pediatric TE cases.

Main Methods:

  • Retrospective analysis of 1776 consecutive pediatric systemic TE cases.
  • Data collected via the 1-800-NO-CLOTS telephone consultation service using standardized forms.
  • Inclusion criteria focused on children with systemic TE managed by clinicians using the service.

Main Results:

  • Infants under one year (47%), including neonates (26%), comprised the largest age group with TE.
  • Venous TE (74%) was the most frequent manifestation, though arterial TE was more common in neonates and children with cardiac issues.
  • Central catheters were the most common risk factor (present in 2/3 of cases), with 90% of children having at least one risk factor.

Conclusions:

  • Pediatric TE, particularly in neonates, requires specific attention due to its prevalence and unique characteristics.
  • Risk factors, notably central venous catheters, are almost always present in pediatric TE cases.
  • Significant heterogeneity exists in the treatment of pediatric TE, suggesting a need for standardized approaches.

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