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Human odontoblasts contain S-100 protein-like immunoreactivity
T Lombardi1, R Di Felice, J Samson
1Division of Stomatology and Oral Surgery, Dental School of Medicine, Faculty of Medicine, University of Geneva, Switzerland.
The Anatomical Record
|February 1, 1992
Summary
S-100 protein, found in various cell types, was detected in human odontoblasts. This suggests S-100 protein plays a role in odontoblast functions.
Area of Science:
- Cell Biology
- Biochemistry
- Histology
Background:
- S-100 protein comprises three isoforms (S-100ao, S-100a, S-100b).
- Initially identified in the nervous system, S-100 protein is now recognized in diverse cell types, including neuroectodermal and non-neuroectodermal origins.
- These cell types include melanocytes, glial cells, Langerhans cells, adipocytes, and chondrocytes.
Purpose of the Study:
- To investigate the presence and localization of S-100 protein in human odontoblasts.
- To explore the potential functional role of S-100 protein in odontoblasts.
Main Methods:
- Immunoperoxidase labeling experiments were employed.
- A specific polyclonal antibody targeting S-100 protein was utilized.
Main Results:
- S-100 protein was successfully detected within the cytoplasm of human odontoblasts.
- The immunoperoxidase staining confirmed the presence of S-100 protein in these specialized dental cells.
Conclusions:
- The findings indicate that S-100 protein is present in human odontoblasts.
- This presence suggests a potential role for S-100 protein in the physiological functions of odontoblasts.