Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla
Lana G Kaiser1, Norbert Schuff, Nathan Cashdollar
1Department of Radiology, University of California-San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA. lkaiser@itsa.ucsf.edu
Abstract:
The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects.
