Microbial polythioesters
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Updated: Aug 21, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Tina Lütke-Eversloh1, Alexander Steinbüchel
1Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität Münster, Corrensstrasse 3, D-48149 Münster, Germany.
Abstract:
This feature article describes the current knowledge on biosynthesis of polythioesters (PTEs), which are exclusively accumulated by microorganisms capable to synthesize the well-known polyhydroxyalkanoates (PHAs). Two bacterial PTE biosynthesis systems are discussed, both are depending on the cultivation conditions and appropriate feeding regimes. The first system comprises the production of PTE copolymers by Ralstonia eutropha, and the second system has been established in recombinant Escherichia coli to produce PTE homopolymers. Furthermore, synthetic PTEs and other related sulfur containing biopolymers are briefly summarized.
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