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Updated: Aug 21, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
Published on: September 6, 2012
Peptide/protein hybrid materials: enhanced control of structure and improved performance through conjugation of
Guido W M Vandermeulen1, Harm-Anton Klok
1Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
Abstract:
The conjugation of peptides/proteins and synthetic polymers is a useful strategy to overcome some of the limitations related to the use of the individual components. This review will highlight two aspects: enhanced structural control at the nanometer level and improved performance, in particular with respect to biomedical applications. In the former case, peptide sequences are mainly used to mediate self-assembly of synthetic polymers. In the latter case, conjugation of an appropriate synthetic polymer to a pharmaceutically active peptide/protein can, for example, prevent premature enzymatic degradation and enhance blood circulation times, which is therapeutically advantageous.
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