Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanced biocompatibility in biostable poly(carbonate)urethane.

Shan-Hui Hsu1, Yu-Chih Kao, Zu-Chang Lin

  • 1Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan. shhsu@nchu.edu.tw

Macromolecular Bioscience
|October 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "Enhanced Biocompatibility and Differentiation Capacity of Mesenchymal Stem Cells on Poly(dimethylsiloxane) by Topographically Patterned Dopamine".

ACS applied materials & interfaces·2026
Same author

Layer-by-Layer Surface-Modified Supramolecular Fullerene Microrods for Cell Feeding.

ACS applied materials & interfaces·2026
Same author

Correction to "Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen-Gold Nanocomposites".

ACS applied materials & interfaces·2026
Same author

Self-healing chitosan-catechol hydrogel with tailored self-assembled fibrillar or micellar structures for biomedical applications.

Carbohydrate polymers·2026
Same author

Corrigendum to "Functional engineered mesenchymal stem cells with fibronectin‑gold composite coated catheters for vascular tissue regeneration" [Nanomed: Nanotechnol Biol Med 14 (2018) 699-711].

Nanomedicine : nanotechnology, biology, and medicine·2026
Same author

A biodegradable polyurethane-gelatin nanocomposite cryogel with shape-memory properties for information encryption and bilayer actuation.

Acta biomaterialia·2026

Poly(carbonate)urethane (PCU) shows improved biostability and biocompatibility compared to poly(ether)urethane (PEU). PCU

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Science

Background:

  • Polyurethanes are widely used in biomedical applications.
  • Biostability and biocompatibility are critical performance metrics for medical devices.
  • Poly(ether)urethane (PEU) and poly(carbonate)urethane (PCU) are common polyurethane types with varying properties.

Purpose of the Study:

  • To synthesize and compare the biostability and in vitro biological performance of MDI-based PEU and PCU.
  • To investigate the relationship between material structure, protein adsorption, and cellular response.
  • To evaluate the potential of PCU as a superior biomaterial.

Main Methods:

  • Synthesis of PEU and PCU using MDI and distinct soft segments (poly(tetramethylene oxide) for PEU, poly(hexyl, ethyl)carbonate diol for PCU).

Related Experiment Videos

  • Assessment of material biostability.
  • In vitro evaluation of biological performance, including cellular attachment, proliferation, platelet activation, and monocyte activation.
  • Analysis of surface protein adsorption (albumin, fibrinogen) and micro-phase separation.

    • Main Results:

    • PCU exhibited enhanced biostability compared to PEU.
    • PCU demonstrated improved in vitro biological performance, including better cellular attachment and proliferation.
    • PCU showed reduced platelet and monocyte activation compared to PEU.
    • Larger micro-phase separation (approx. 25 nm) in PCU correlated with distinct protein adsorption patterns and enhanced biocompatibility.

    Conclusions:

    • MDI-based PCU offers superior biostability and biocompatibility over PEU.
    • The enhanced biocompatibility of PCU is attributed to its distinct micro-phase separation and resulting protein adsorption characteristics.
    • PCU presents a promising alternative for biomedical applications requiring improved biological performance.