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Locally produced bovine bone sponge as a haemostatic agent
C Y Ang1, A R Samsudin, A M Al-S Karima
1National Tissue Bank, School of Medical Sciences, University Sains Malaysia.
The Medical Journal of Malaysia
|October 8, 2004
Summary
A novel bovine bone sponge, derived from calf bone, demonstrates superior hemostatic properties and reduces alveolar bone resorption post-extraction compared to commercial agents.
Area of Science:
- Biomaterials Science
- Dental Materials
- Tissue Engineering
Background:
- Developing effective bone graft substitutes is crucial in dentistry.
- Bovine bone-derived materials offer potential biocompatibility and osteoconductivity.
- Evaluating local production of such materials ensures accessibility and quality control.
Purpose of the Study:
- To assess the morphological and biological characteristics of a locally manufactured bovine bone sponge.
- To compare its efficacy against a commercial hemostatic agent in dental applications.
- To investigate its hemostatic and bone resorption inhibitory potential.
Main Methods:
- Preparation of bovine bone sponge from calf bone.
- Analysis of endotoxin levels, surface properties, pore size, and water uptake.
- Evaluation of hemostatic properties and inhibition of alveolar bone resorption in a sheep extraction model.
Main Results:
- The locally produced bovine bone sponge exhibited favorable morphological and biological properties.
- It demonstrated a significantly more effective hemostatic effect than the commercial agent.
- The material significantly reduced bleeding time and alveolar bone resorption in the sheep model.
Conclusions:
- Locally produced bovine bone sponge is a viable alternative for dental applications.
- It possesses superior hemostatic capabilities and effectively minimizes alveolar bone loss.
- This material holds promise for enhancing bone regeneration and healing in dentistry.