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Synthesis of nanosized hydroxyapatite powders
1School of Material and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang.
The Medical Journal of Malaysia
|October 8, 2004
Summary
Mechanochemical synthesis of hydroxyapatite from calcium pyrophosphate and calcium carbonate produced multiple phases. Further research aims to achieve single-phase hydroxyapatite with excess hydroxyl groups.
Area of Science:
- Materials Science
- Solid-State Chemistry
- Nanotechnology
Background:
- Hydroxyapatite is a crucial biomaterial with applications in bone regeneration and dentistry.
- Current synthesis methods can be energy-intensive or yield impure products.
Purpose of the Study:
- To investigate the mechanochemical synthesis of hydroxyapatite using calcium pyrophosphate and calcium carbonate.
- To identify the phases formed during the solid-state reaction.
- To establish a foundation for producing single-phase hydroxyapatite.
Main Methods:
- Solid-state reaction involving calcium pyrophosphate and calcium carbonate.
- Mechanochemical milling in distilled water for 8 hours.
- Drying and calcination at 1100°C for 1 hour.
- Phase analysis using X-ray diffraction (XRD).
Main Results:
- The mechanochemical synthesis resulted in the formation of hydroxyapatite along with other unidentified phases.
- X-ray diffraction confirmed the presence of multiple crystalline phases, not solely hydroxyapatite.
Conclusions:
- The mechanochemical approach using calcium pyrophosphate and calcium carbonate yields a multi-phase product.
- This study serves as a preliminary step towards optimizing conditions for single-phase hydroxyapatite synthesis.
- Future work will focus on controlling the reaction to achieve hydroxyapatite with an excess hydroxyl group.