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Updated: Aug 21, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
Published on: August 22, 2016
Collagen fibers an important entity in skin tissues remodeling
M M Norhayati1, A L Mazlyzam, R Asmah
1Institute of Bioscience, Universiti Putra Malaysia.
Abstract:
Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) evaluation were carried out in the in vivo skin construct using fibrin as biomaterial. To investigate its progressive remodeling, nude mice were grafted and the Extracellular Matrix (ECM) components were studied at four and eight weeks post-grafting. It was discovered that by 4 weeks of remodeling the skin construct acquired its native structure.
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