Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caveolae meet endosomes: a stable relationship?

Robert G Parton1

  • 1Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Queensland 4072, Australia.

Developmental Cell
|October 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish.

eLife·2026
Same author

The formation, dynamics, and disassembly of caveolae.

Current opinion in cell biology·2026
Same author

Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response.

Science immunology·2026
Same author

A lipid-centric view of endocytosis by caveolae.

Nature cell biology·2026
Same author

Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion.

Nature metabolism·2026
Same author

Trans-Endothelial Trafficking in Zebrafish: Nanobio Interactions of Polyethylene Glycol-Based Nanoparticles in Live Vasculature.

ACS nano·2026
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

New research reveals that caveolae, crucial for cellular transport, interact with caveosomes and early endosomes. These interactions form stable membrane domains within early endosomes, enabling regulated cargo incorporation.

Area of Science:

  • Cell Biology
  • Membrane Trafficking
  • Endocytosis

Background:

  • Endocytic trafficking of caveolae has long been debated.
  • Understanding caveolae dynamics is key to cellular processes.

Purpose of the Study:

  • To elucidate the trafficking pathways of caveolae.
  • To investigate the interaction of caveolae with endosomal compartments.
  • To characterize the nature of caveolin-enriched membrane domains.

Main Methods:

  • Live-cell imaging techniques.
  • Fluorescently tagged proteins to track caveolae and endosomes.
  • Biochemical assays to analyze membrane domain stability.

Main Results:

  • Budded caveolae were observed to interact with both caveosomes and early endosomes.

Related Experiment Videos

  • Caveolin-enriched regions within early endosomal membranes form stable, distinct domains.
  • These stable domains exhibit regulated incorporation of cargo.

    • Conclusions:

    • Caveolae trafficking involves dynamic interactions with multiple endosomal compartments.
    • Stable, caveolin-enriched domains in early endosomes play a role in cargo selection and uptake.
    • This study clarifies a long-standing controversy in caveolae endocytosis.