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No adverse hemodynamic interaction between sildenafil and red wine.
Stephen J Leslie1, Graham Atkins, James J Oliver
1Centre for Cardiovascular Science, The University of Edinburgh, Western General Hospital, United Kingdom. s.j.leslie@ed.ac.uk
Clinical Pharmacology and Therapeutics
|October 8, 2004
Summary
This study found no significant adverse hemodynamic interactions between sildenafil (Viagra) and red wine consumption. Healthy men taking sildenafil with red wine showed no clinically important changes in blood pressure or heart rate.
Area of Science:
- Cardiovascular Pharmacology
- Pharmacodynamics
Background:
- Sildenafil citrate (Viagra) is a phosphodiesterase type 5 inhibitor used for erectile dysfunction, enhancing nitric oxide-mediated vasodilation.
- Alcohol, specifically red wine, has complex vascular effects potentially involving nitric oxide, raising concerns about interactions with vasodilators.
Purpose of the Study:
- To investigate the potential hemodynamic interaction between sildenafil and red wine in healthy male subjects.
- To assess the combined effects on blood pressure, heart rate, and cardiac index.
Main Methods:
- A 4-way, double placebo-controlled, randomized crossover study involving eight healthy men.
- Administration of 100 mg sildenafil, 750 mL red wine, or the combination, with hemodynamic measurements every 15 minutes for 180 minutes.
Main Results:
- Red wine significantly increased cardiac index (15%) and heart rate (27%), with transient changes in mean arterial pressure.
- Sildenafil reduced peripheral vascular resistance (24%) and mean arterial pressure (7%) without affecting cardiac index or heart rate.
Conclusions:
- No clinically significant adverse hemodynamic interactions were observed between sildenafil and red wine.
- The combination of sildenafil and red wine does not appear to pose a major cardiovascular risk in healthy individuals.