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Induction dose-responses studies with propofol and thiopentone.
M Naguib1, A Sari-Kouzel, M Seraj
1Department of Critical Care Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain.
British Journal of Anaesthesia
|March 1, 1992
Summary
Propofol and thiopentone potency for anesthesia induction was compared. Results show different dose-response curves for verbal commands versus eyelash stimulation, indicating distinct endpoints cannot define each other.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol and thiopentone are common anesthetic agents.
- Assessing anesthetic potency requires clear endpoint definition.
Purpose of the Study:
- To compare the relative potencies of propofol and thiopentone.
- To evaluate different endpoints for measuring anesthetic induction.
Main Methods:
- Log-probit dose-response curves were generated for propofol and thiopentone.
- Endpoints assessed included abolition of response to verbal commands and eyelash stimulation.
- Data collected at 30, 60, and 90 seconds post-induction in 96 patients.
Main Results:
- Propofol ED50 ranged from 1.16-1.72 mg/kg; ED95 ranged from 2.18-3.27 mg/kg.
- Thiopentone ED50 ranged from 1.81-3.55 mg/kg; ED95 ranged from 5.11-6.70 mg/kg.
- Potency ratio of propofol to thiopentone varied from 1:1.27 to 1:2.88.
Conclusions:
- Different endpoints yield distinct dose-response curves for anesthetic induction.
- A single endpoint's dose-response curve cannot define another endpoint's potency.