Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High resolution MR based polymer dosimetry versus film densitometry: a systematic study based on the modulation

A Berg1, M Pernkopf, C Waldhäusl

  • 1Institut für Medizinische Physik, Medizinische Universität Wien, Währingerstr 13, A-1090 Wien, Austria. andreas.berg@univie.ac.at

Physics in Medicine and Biology
|October 9, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Barriers and Facilitators to Topical Fluoride Varnish Application in Well-Child Visits.

JDR clinical and translational research·2025
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Osseointegration of photodynamic active biomaterials for bone regeneration in an animal bone model over a period of 12 months.

Dental materials : official publication of the Academy of Dental Materials·2023
Same author

Cubital Tunnel Decompression: Equivalent Outcome Scores when Procedure Performed with Local versus General Anesthetic.

Journal of hand and microsurgery·2019
Same author

Antimicrobial photodynamic active biomaterials for periodontal regeneration.

Dental materials : official publication of the Academy of Dental Materials·2018
Same author

Acute kidney injury following enhanced recovery for orthopaedic joint replacement surgery-role of preoperative kidney disease?

British journal of anaesthesia·2017

Magnetic resonance-based polymer dosimetry (MRPD) offers high-resolution relative dosimetry. This study introduces the dose modulation transfer function (DMTF) to assess spatial resolution, achieving sub-0.04 mm3 voxel sizes and potentially outperforming film dosimetry.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Medical Imaging

Background:

  • Modern radiation therapy requires precise dosimetry for high dose localization in small volumes.
  • Existing dosimetry methods struggle with sub-millimeter dose variations and dose imaging.
  • Magnetic resonance-based polymer dosimetry (MRPD) shows promise for high-resolution relative dosimetry but requires spatial resolution investigation.

Purpose of the Study:

  • To introduce and experimentally validate the dose modulation transfer function (DMTF) for assessing spatial resolution in dose imaging systems.
  • To quantitatively compare the spatial resolution of polymer gel dosimetry with film dosimetry.
  • To investigate the potential of MRPD for high-resolution relative dosimetry in radiation therapy.

Main Methods:

Related Experiment Videos

  • Developed a theoretical construct for the dose modulation transfer function (DMTF).
  • Irradiated polymer gel samples with Co-60 photons through an absorber grid with spatial periods down to 280 micrometers.
  • Visualized dose modulation using high-resolution, parameter-selective (T2) magnetic resonance imaging (MRI) on a 3T scanner, achieving voxel sizes below 0.04 mm3.

    • Main Results:

    • Achieved significantly smaller voxel sizes (below 0.04 mm3) compared to previous MRPD studies.
    • Observed dose modulations with 22% amplitude at approximately 2 line pairs per millimeter.
    • Demonstrated that MR-based gel dosimetry at 200 microm pixel resolution may offer superior relative spatial resolution compared to standard film-scanner systems.

    Conclusions:

    • The DMTF approach provides a robust method for evaluating spatial resolution in dose imaging systems.
    • MR-based polymer gel dosimetry, particularly at high resolutions, shows significant potential for precise relative dosimetry in radiation therapy.
    • This technique may offer advantages over conventional film dosimetry for assessing fine dose variations.