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Related Experiment Videos

RANTES: a genetic risk marker for multiple sclerosis.

Radhika Gade-Andavolu1, David E Comings, James MacMurray

  • 1Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst # 308, 39000 Bob Hope Dr, Rancho Mirage, CA 92270, USA. randavolu@gridonline.org

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 9, 2004
PubMed
Summary
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The RANTES gene

Area of Science:

  • Neuroimmunology
  • Genetics

Background:

  • Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a beta-chemokine.
  • RANTES has been detected in brain lesions of multiple sclerosis (MS) patients, suggesting a potential role in the disease.

Purpose of the Study:

  • To screen two functional polymorphisms in the proximal promoter region of the RANTES gene.
  • To investigate the association of these polymorphisms with MS in patients versus controls.

Main Methods:

  • Examined 140 postmortem brain samples from MS patients and 216 peripheral blood samples from control subjects.
  • Analyzed RANTES promoter polymorphisms: -28C/G and -403G/A.
  • All subjects were non-Hispanic Caucasians.

Main Results:

Related Experiment Videos

  • A significant association was found between the RANTES -403G/A polymorphism and MS (odds ratio, 2.359; P=0.0001).
  • The RANTES -28C/G polymorphism was not significantly associated with MS.
  • The -28G allele showed a significant association with both early onset MS (P=0.031) and longer survival (P=0.006).

Conclusions:

  • The RANTES gene is significantly associated with multiple sclerosis.
  • The association is complex, involving specific polymorphisms and alleles that may influence disease onset and progression.