Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences

Tonic activation of excitatory and inhibitory receptors, by the ambient concentration of neurotransmitters in the extracellular space of the brain, has been suggested to underlie phenomena as diverse as relapse to cocaine use by reward pathways in the striatum, sparse coding of motor information in the cerebellum, and control of the development of the cerebral and cerebellar cortices. Here we assess the mechanisms which may determine the ambient levels of excitatory and inhibitory neurotransmitters, and consider their likely effect on information processing.