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Changes in decidual stromal cell function associated with labour.

H Khan1, O Ishihara, M H Sullivan

  • 1Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

British Journal of Obstetrics and Gynaecology
|January 1, 1992
PubMed
Summary
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Decidual stromal cells significantly increase prostaglandin production after labor. This suggests these cells are a key source of prostaglandins during childbirth, impacting labor processes.

Area of Science:

  • Reproductive biology
  • Cellular physiology
  • Biochemistry

Background:

  • Prostaglandins play a crucial role in labor and delivery.
  • The decidua, a specialized uterine lining during pregnancy, is a potential source of prostaglandins.
  • Understanding decidual prostaglandin production is vital for comprehending labor mechanisms.

Purpose of the Study:

  • To investigate if decidual cells alter prostaglandin production following labor.
  • To quantify changes in prostaglandin E2 and F2 alpha levels in decidual cells post-labor.

Main Methods:

  • Decidual stromal cells and macrophages were isolated from women before and after labor.
  • Prostaglandin E2 and F2 alpha production was measured in cultured cells.
  • Immunocytochemistry was used to assess cyclooxygenase enzyme expression in decidual cells.

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Main Results:

  • Decidual stromal cells from post-labor samples produced 30-fold higher levels of prostaglandins E2 and F2 alpha compared to pre-labor samples.
  • This elevated prostaglandin production persisted for up to 72 hours in culture.
  • A significant increase in cyclooxygenase-positive cells was observed, rising from <5% to >95% post-labor.

Conclusions:

  • Decidual stromal cells release significantly increased amounts of prostaglandins E2 and F2 alpha after labor.
  • These findings indicate that decidual stromal cells are a major source of prostaglandins during labor.
  • Decidual prostaglandin production is a key factor in the physiological processes of labor.