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Related Experiment Videos

Somatotropic function: the somatomedin hypothesis revisited.

T D Etherton1

  • 1Department of Dairy and Animal Science, Pennsylvania State University, University Park 16802, USA. tetherton@psu.edu <tetherton@psu.edu>

Journal of Animal Science
|October 9, 2004
PubMed
Summary

Growth hormone (somatotropin) discovery revolutionized animal agriculture. Recombinant porcine somatotropin enhances growth, improves feed efficiency, and reduces fat in pigs.

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Area of Science:

  • Endocrinology
  • Animal Science
  • Biotechnology

Background:

  • Discovery of growth hormone (somatotropin, ST) in 1922 from anterior pituitary extracts.
  • Advancements in recombinant DNA technology enabled commercial ST products for animal agriculture.

Observation:

  • Porcine ST (pST) administration significantly impacts pig growth metrics.
  • Maximal pST doses (100 microg x kg BW(-1) x d(-1)) over 30-77 days were studied.

Findings:

  • Average daily gain increased by 10-20%.
  • Productive efficiency improved by 13-33%.
  • Lipid accretion decreased by up to 80%, while protein deposition increased by up to 70%, with a 10-15% decrease in feed intake.

Implications:

Related Experiment Videos

  • ST's effects are mediated directly and indirectly via somatomedin (insulin-like growth factor-I).
  • The evolution of the somatomedin hypothesis explains ST and IGF-I's diverse biological actions.
  • Understanding ST action is crucial for optimizing animal growth and productivity.