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Published on: February 17, 2023
Pediatric infection due to multiresistant Salmonella enterica serotype Infantis in Honduras
Ernesto Liebana1, Miranda Batchelor, Carmen Torres
1Instituto de Acuicultura, Universidad de Santiago de Compostela, Spain. e.liebana@vla.defra.gsi.gov.uk
Abstract:
We report the case of a pediatric patient with a Salmonella enterica serotype Infantis infection. Detailed microbiological investigation revealed that this isolate carries four beta-lactamase genes (bla(TEM-1b) variant, bla(SHV-5), bla(CTX-M-15), and bla(CMY-2)) conferring resistance to all beta-lactams but imipenem. This is the first report of a Salmonella isolate with CTX-M and AmpC enzymes on the American continent, the first report of bla(CMY-2) in Salmonella serotype Infantis, and the first report of bla(CTX-M-15) in the genus Salmonella.
Insights
A pediatric Salmonella Infantis infection revealed extensive antibiotic resistance due to multiple beta-lactamase genes. This case highlights the emergence of novel resistance mechanisms in Salmonella, posing a significant public health challenge.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Salmonella enterica serotype Infantis is an important foodborne pathogen.
- The emergence of antibiotic resistance in Salmonella poses a global health threat.
Observation:
- A pediatric patient presented with Salmonella Infantis infection.
- Microbiological investigation identified four beta-lactamase genes: bla(TEM-1b) variant, bla(SHV-5), bla(CTX-M-15), and bla(CMY-2).
Findings:
- The identified genes confer resistance to all beta-lactam antibiotics except imipenem.
- This is the first report of Salmonella with CTX-M and AmpC enzymes in the Americas.
- This is the first report of bla(CMY-2) in Salmonella Infantis and bla(CTX-M-15) in the Salmonella genus.
Implications:
- This case underscores the rapid evolution and spread of antimicrobial resistance genes.
- Highlights the need for enhanced surveillance of antibiotic-resistant Salmonella strains.
- Emphasizes the importance of infection control measures to prevent the dissemination of resistant bacteria.
