Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electric fields within cells as a function of membrane resistivity--a model study.

Brian J Mossop1, Roger C Barr, David A Zaharoff

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA.

IEEE Transactions on Nanobioscience
|October 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thecoperitoneal shunt placement for extensive spinal adhesive arachnoiditis or lumbosacral outlet obstruction with syringomyelia.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Is Rituximab Suitable for Patients with Idiopathic Membranous Nephropathy Who are Seronegative for Anti-PLA2R Antibody?

Drug design, development and therapy·2026
Same author

A scoring model based on oral contrast-enhanced ultrasound for the diagnosis of gastric cancer: A preliminary study.

Ultrasound (Leeds, England)·2026
Same author

Comparison of Foramen Magnum and Foramen of Magendie Dredging Versus Posterior Fossa Decompression With Duraplasty in Adults With Chiari I Malformation-Syringomyelia: A Propensity-Matched Study.

Neurosurgery·2026
Same author

Efficacy of tegileridine combined with intercostal nerve block for postoperative analgesia following thoracoscopic pulmonary resection: a study protocol for a randomised controlled trial.

BMJ open·2026
Same author

Functional role of Galectin-9 in nucleic acid trafficking and transcription post-electrotransfection.

NAR molecular medicine·2026

Externally applied electric fields create significant intracellular electric fields, which increase as membrane resistance decreases. These fields are crucial for understanding electric field therapies.

Area of Science:

  • Biophysics
  • Computational Biology

Background:

  • Externally applied electric fields are used in therapies, but their intracellular effects are poorly understood.
  • Understanding intracellular electric fields is key to elucidating mechanisms of electric field-mediated therapies.

Purpose of the Study:

  • To determine the intracellular electric field and transmembrane potential in a cell model under an applied electric field.
  • To investigate the relationship between intracellular electric field, transmembrane potential, and membrane resistance (Rm).

Main Methods:

  • A three-dimensional computational model of a 10-microm spherical cell was used.
  • Simulations were performed for an applied electric field of 100 V/cm.
  • The intracellular electric field and transmembrane potential were calculated across a range of membrane resistance values.

Related Experiment Videos

Main Results:

  • The intracellular electric field increased from 1.1 mV/cm to 111 mV/cm as membrane resistance decreased from 10,000 to 100 Ω·cm².
  • Transmembrane potential remained relatively constant over this range of membrane resistance.
  • Transmembrane potential decreased only when membrane resistance dropped below 1 Ω·cm².

Conclusions:

  • Intracellular electric field magnitude is dependent on membrane resistance within the physiological range.
  • The calculated intracellular electric fields may be significant and should be considered in the context of electric field-mediated therapies.