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Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana
Yong Kim1, Seong-Cheol Bang, Ji-Hyun Lee
1SB Pharmaceutical Co. LTD, 533-2 Bonggok-ri, Banpo-myeon, Gongju-shi 314-923, Chungnam, Korea.
Archives of Pharmacal Research
|October 12, 2004
Abstract:
By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82%) at the dose of 6.4 mg/kg on the BDF1 mice bearing LLC cells.