Related Experiment Video
Updated: Aug 21, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
Published on: April 3, 2013
Cortical development deNUDEd
1Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
Abstract:
The development of the cerebral cortex is a highly orchestrated process of cell division and migration. In this issue of Neuron, Feng and Walsh and Shu et al. examine the roles of two related proteins, Nde1 (mNudE) and Ndel1 (NUDEL), in cortical development. These proteins play a crucial role in centrosome positioning, with Nde1 functioning mainly during progenitor cell divisions and Ndel1 functioning in neuronal migration.
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