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Updated: Aug 21, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Translocation (16;18)(p13;q21.3) in follicular lymphoma
Mandana Mahmoodi1, Silvio S Tanev, Hope H Punnett
1Department of Pathology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA.
Abstract:
We describe a novel t(16;18)(p13;q21.3) in a male patient with follicular lymphoma. This unique chromosomal rearrangement has never been described in patients with follicular lymphoma. The breakpoint of 16p13 has several hematopoietic neoplasm-related genes such as MHC2TA, a master regulatory gene for HLA-D, and BCMA, tumor necrosis factor receptor super-family. The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. The diagnostic and prognostic significance of this new translocation is yet to be determined.

