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Updated: Aug 21, 2026

Protein Misfolding Cyclic Amplification of Prions
Published on: November 7, 2012
Amino acid sequence of the Felis catus prion protein
Dominikus A Lysek1, Lucas G Nivon, Kurt Wüthrich
1Institut für Molekularbiologie und Biophysik, HPK G5, Eidgenössische Technische Hochschule Zürich, Honggerberg, Zürich CH-8093, Switzerland. lysek@mol.biol.ethz.ch
Abstract:
A new determination of the house cat (Felis catus) prion protein gene sequence (fPrnp), which has so far been subject of controversy, is reported. The newly determined fPrnp sequence is similar to dog (Canis familiaris) and mink (Mustela putorius) Prnp, but differs significantly from both fPrnp sequences that were previously deposited in the GenBank. Comparison of the canine and feline prion protein sequences suggests a set of amino acid replacements relative to bovine PrP that might relate to the observed different susceptibilities of the two species to TSE infection by ingestion of BSE-infected beef.
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