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Related Experiment Videos

Tau gene (MAPT) sequence variation among primates.

Max Holzer1, Molly Craxton, Ross Jakes

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK. holm@medizin.uni-leipzig.de

Gene
|October 12, 2004
PubMed
Summary
This summary is machine-generated.

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Researchers sequenced primate Tau genes, finding chimpanzee Tau nearly identical to human Tau. Genetic differences may explain why chimpanzees show resistance to tau pathology in neurodegenerative diseases.

Area of Science:

  • Neuroscience
  • Genetics
  • Primatology

Background:

  • Filamentous tau deposits characterize human neurodegenerative diseases.
  • Nonhuman primates exhibit varied susceptibility to tau pathology.
  • Limited information exists on nonhuman primate Tau organization and sequence.

Purpose of the Study:

  • Sequence Tau exons 1-13 and flanking intronic regions in great apes.
  • Investigate the Saitohin-containing region in intron 9 of selected primates.
  • Compare primate Tau sequences to understand differential susceptibility to tau pathology.

Main Methods:

  • Sequencing of Tau exons 1-13 and adjacent intronic regions.
  • Targeted sequencing of the Saitohin-containing region in intron 9.
  • Comparative sequence analysis of Tau and Saitohin across species.

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Main Results:

  • Chimpanzee, gorilla, and gibbon Tau sequences were determined.
  • Chimpanzee Tau showed 100% identity to human Tau; gorilla (99.5%) and gibbon (99.0%) showed high identity.
  • Chimpanzee DNA exhibited polymorphisms in intron 9 and near exon 10, differing from human Tau.
  • Saitohin had an intact open reading frame in chimpanzees and gorillas, but not gibbons or macaques.

Conclusions:

  • High sequence similarity between human and chimpanzee Tau suggests other genetic factors influence tau pathology.
  • Identified genetic variations in chimpanzee Tau may contribute to their apparent resistance to developing tau pathology.
  • Differential Saitohin gene integrity across species warrants further investigation regarding tau pathology.