Related Experiment Video

Updated: Aug 21, 2026

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
07:59

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

Angiogenesis in colorectal cancer: therapeutic implications and future directions

Jill Allen1, Emily K Bergsland

  • 1University of California-San Francisco Comprehensive Cancer Center, 1600 Divisidero, 4th Floor, Box 1705, San Francisco, CA 94115, USA.

Hematology/Oncology Clinics of North America
|October 12, 2004
PubMed

Insights

This study explores how targeting angiogenesis, the formation of new blood vessels, can treat colorectal cancer. It examines current therapeutic strategies and future research avenues for this disease.

Area of Science:

  • Oncology
  • Vascular Biology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a significant global health concern.
  • Angiogenesis plays a critical role in tumor growth and metastasis in CRC.
  • Understanding the mechanisms of angiogenesis is crucial for developing effective therapies.

Purpose of the Study:

  • To review the therapeutic implications of targeting angiogenesis in colorectal cancer.
  • To discuss the future directions and potential of anti-angiogenic therapies for CRC.
  • To highlight the importance of angiogenesis in CRC progression and treatment.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of current anti-angiogenic drugs and treatment strategies.
  • Discussion of emerging research and novel therapeutic targets.

Main Results:

  • Anti-angiogenic therapies have shown promise in treating colorectal cancer.
  • Combinatorial approaches may enhance treatment efficacy.
  • Resistance to anti-angiogenic therapy is a significant challenge.

Conclusions:

  • Targeting angiogenesis remains a key strategy in colorectal cancer treatment.
  • Further research is needed to overcome resistance and optimize therapeutic outcomes.
  • Future directions include novel drug development and personalized treatment approaches.

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...