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Phragmalin limonoids from Chukrasia tabularis
Munehiro Nakatani1, Samir A M Abdelgaleil, Mona M G Saad
1Department of Chemistry and Bioscience, Faculty of Science, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan. nakat@mail.sci.kagoshima-u.ac.jp
Phytochemistry
|October 12, 2004
Summary
Six new phragmalin limonoids were discovered in Chukrasia tabularis root bark. These compounds, tabulalin and tabulalides A-E, showed antifeedant properties, indicating potential pest control applications.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Entomology
Background:
- Chukrasia tabularis (Meliaceae) is a plant species known for its potential medicinal properties.
- Limonoids are a class of terpenoids found in Meliaceae plants, often exhibiting biological activity.
Purpose of the Study:
- To isolate and characterize novel phragmalin limonoids from the root bark of Chukrasia tabularis.
- To evaluate the antifeedant properties of the isolated compounds against insect pests.
Main Methods:
- Phytochemical investigation of Chukrasia tabularis root bark extract.
- Structure elucidation using comprehensive spectroscopic techniques (e.g., NMR, MS).
- Bioassays to assess the antifeedant activity of the isolated limonoids.
Main Results:
- Six phragmalin limonoids, including tabulalin and five new compounds (tabulalides A-E), were successfully isolated.
- The structures of these compounds were determined through detailed spectroscopic analysis.
- The isolated limonoids demonstrated significant antifeedant properties.
Conclusions:
- The root bark of Chukrasia tabularis is a rich source of diverse phragmalin limonoids.
- Tabulalin and tabulalides A-E represent new chemical entities with potential applications in pest management due to their antifeedant effects.