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Related Experiment Videos

Is pericardium a suitable calibration reference in integrated backscatter analysis?

Wen-Chol Voon1, Chaw-Chi Chiu, Ho-Ming Su

  • 1Division of Cardiology, Kaohsiung Medical University, Kaohsiung, Taiwan. wcvoon@giga.net.tw

Ultrasound in Medicine & Biology
|October 12, 2004
PubMed
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Pericardium is not an ideal calibration reference for integrated backscatter (IBS) analysis in cardiac tissue studies. Its wide variation in calibrated intensity limits its use for population-based research.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Histopathology

Background:

  • Integrated backscatter (IBS) is a quantitative ultrasound technique used for tissue characterization.
  • Accurate calibration is crucial for reliable IBS analysis, especially in population studies.
  • The pericardium is a potential, but unevaluated, reference tissue for IBS calibration.

Purpose of the Study:

  • To assess the suitability of normal pericardium as a calibration reference for integrated backscatter (IBS) analysis.
  • To determine the variability and reliability of IBS measurements from pericardial specimens.

Main Methods:

  • Grossly normal pericardial specimens from 23 patients were analyzed using 2-D IBS imaging.
  • Specimens were immersed in saline, and IBS images were acquired at 50 and 70 dB gain settings.

Related Experiment Videos

  • Intraobserver and interobserver variability were calculated, along with the range of calibrated IBS intensity.

    • Main Results:

    • Intraobserver limits of agreement were -1.2 to 1.4 dB; interobserver limits were -1.6 to 2.2 dB.
    • Calibrated IBS intensity of pericardium showed significant variation: -13 ± 5 dB (50 dB gain) and -10 ± 4 dB (70 dB gain).
    • The range of calibrated IBS intensity was wide, from -5 to -29 dB and -4 to -22 dB.

    Conclusions:

    • Pericardium exhibits considerable variation in calibrated IBS intensity.
    • This variability makes pericardium an unsuitable calibration reference for population studies in cardiac tissue characterization.
    • Further research is needed to identify reliable calibration standards for IBS analysis.