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[Enuresis in children with sickle cell disease]
J R Mabiala Babela1, R Loumingou, A Pemba-Loufoua
1Service de pédiatrie, CHU de Brazzaville, BP 32, Congo. j.mabiala.babela@caramail.com <j.mabiala.babela@caramail.com>
Summary
Enuresis (bedwetting) is common in children with sickle cell disease (SCD), affecting over 50%. Higher rates of enuresis correlate with disease severity, including anemia and pain crises.
Area of Science:
- Pediatric Hematology
- Urology
- Epidemiology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder with significant health implications for children.
- Enuresis, or involuntary urination during sleep, is a common childhood condition, but its prevalence in children with SCD is not well-established.
Purpose of the Study:
- To investigate the prevalence and characteristics of enuresis in children with sickle cell disease (SCD).
- To identify potential risk and etiological factors associated with enuresis in this population.
Main Methods:
- A cross-sectional study involving 987 children aged 5-20 years.
- Two groups were compared: 456 children with sickle cell disease (hemoglobin SS) and 531 healthy children, matched for age and sex.
Main Results:
- Enuresis prevalence was significantly higher in children with SCD (50.9%) compared to controls (16.4%).
- Higher rates were observed in girls and persisted at age 16. Anemia and painful crises were linked to enuresis. A negative correlation was found between hemoglobin F levels and enuresis.
- The frequency of wet nights was significantly higher in the SCD group.
Conclusions:
- Enuresis is a frequent complication in children with sickle cell disease.
- The intensity of enuresis is associated with the severity of the underlying SCD, suggesting a link between disease activity and bladder control.