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Related Experiment Videos

Whipple's disease.

Julio C Bai1, Roberto M Mazure, Horacio Vazquez

  • 1Small Intesting Section, Department of Medicine, Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina. jbai@intramed.net.ar

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|October 12, 2004
PubMed
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Whipple's disease is a rare bacterial infection caused by Tropheryma whipplei. Diagnosis involves tissue assessment and PCR, with antibiotic treatment leading to remission.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Immunology

Background:

  • Whipple's disease is a rare multisystemic infectious disorder.
  • It predominantly affects middle-aged men with variable clinical manifestations and a long prediagnostic course.
  • Characteristic symptoms include weight loss, chronic diarrhea, arthralgias, and low-grade fever.

Purpose of the Study:

  • To describe the characteristics of Tropheryma whipplei, the causative agent of Whipple's disease.
  • To outline diagnostic approaches for Whipple's disease.
  • To review current treatment recommendations and their efficacy.

Main Methods:

  • Histologic assessment of diseased tissue showing macrophage infiltration.
  • Confirmatory diagnostic tests including electron microscopy and polymerase chain reaction (PCR).

Related Experiment Videos

  • Bacterial culture on a human fibroblast cell line.

    • Main Results:

    • Tropheryma whipplei exhibits unique characteristics, including affinity for PAS stain and a trilamellar cell wall.
    • Pathological specimens reveal macrophage infiltration with intracellular bacteria.
    • Genetic sequencing and culture of T. whipplei have been achieved.

    Conclusions:

    • Diagnosis relies on histological findings supported by PCR or electron microscopy.
    • Antibiotic therapy, typically parenteral cephalosporins followed by trimethoprim-sulphamethoxazole, is essential for treatment.
    • This treatment regimen leads to rapid clinical improvement, remission, and reduced relapse rates, including for neurologic compromise.