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Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum
Xing Fu Cai1, Im Seon Lee, Nguyen Tien Dat
1College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Abstract:
Six diterpenoids and two diterpene glycosides were isolated from the dichloromethane and the water fractions of Acanthopanax koreanum roots, respectively. Of these compounds, 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid containing an isovaleryloxy group at C-17 was found to exhibit the strongest inhibitory activity (IC(50), 6.7 microm) against NFAT transcription factor. However, sumogaside, 16alpha-hydroxy-ent-kauran-19-oic acid and paniculosides IV containing a hydroxy group at C-16 or a glycoside at C-4 carboxyl acid showed no activity.
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