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Related Experiment Videos

[Crohn disease in advanced age].

H Fürst1, M Storck, K W Jauch

  • 1Chirurgische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Klinikum Grosshadern.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|January 1, 1992
PubMed
Summary

Late-onset Crohn's disease (over 65) is rare and often affects the lower GI tract. Vascular lesions and transmural inflammation suggest ischemia may contribute to its development.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Geriatric Medicine

Background:

  • Late-onset Crohn's disease (LOD) is a rare condition, typically affecting the distal gastrointestinal tract.
  • Associated conditions like cardiovascular disease and diverticulitis are common in LOD patients.
  • Diagnosis can be delayed due to overlapping symptoms with diverticulitis.

Observation:

  • A retrospective analysis of 10 surgical patients (≥65 years) with Crohn's disease was conducted.
  • Hematochezia (intestinal bleeding) was a symptom in 50% of cases.
  • Granulomas were infrequent (50%), but transmural inflammation was present in all cases.

Findings:

  • Vascular lesions, including intimal/medial thickening and thrombosis, were observed in 80% of specimens.

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  • These vascular changes support the hypothesis of ischemia playing a role in LOD pathogenesis.
  • Histological findings in LOD differ from typical Crohn's disease presentations.

    • Implications:

    • Understanding the role of ischemia could lead to improved diagnostic strategies for late-onset Crohn's disease.
    • Further research into the vascular aspects of LOD is warranted.
    • This study highlights the unique pathological features of Crohn's disease in elderly patients.