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Impact of anemia on outcomes of patients undergoing percutaneous coronary interventions

Eugenia Nikolsky1, Roxana Mehran, Eve D Aymong

  • 1Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York 10022, USA.

The American Journal of Cardiology
|October 13, 2004
PubMed

Insights

Anemia is common in patients undergoing percutaneous coronary intervention (PCI), significantly increasing their risk of death. Lower hematocrit levels independently predict higher mortality rates one year after PCI.

Area of Science:

  • Cardiology
  • Hematology
  • Public Health

Background:

  • Anemia is a prevalent condition affecting cardiovascular disease patients.
  • The impact of anemia on outcomes following percutaneous coronary intervention (PCI) requires further elucidation.

Purpose of the Study:

  • To determine the prevalence of anemia in patients undergoing PCI.
  • To assess the association between anemia and in-hospital and long-term mortality after PCI.

Main Methods:

  • Retrospective analysis of 6,929 patients treated with PCI.
  • Anemia defined by World Health Organization criteria.
  • Statistical analysis including adjustment for confounders.

Main Results:

  • Prevalence of anemia was 24.6% (1,708 patients).
  • Anemic patients were older, more often female and African-American, with higher cardiovascular risk.
  • Anemia significantly correlated with higher in-hospital (1.9% vs 0.4%) and 1-year mortality (12.8% vs 3.5%).
  • Baseline hematocrit was an independent predictor of 1-year mortality (HR 0.93 per 1% increase).

Conclusions:

  • Anemia is a significant comorbidity in patients undergoing PCI.
  • Anemia is associated with substantially increased mortality risk after PCI.
  • Hematocrit level is a critical prognostic factor in this patient population.

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