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Related Experiment Videos

Erectile dysfunction in smokers: a penile dynamic and vascular study.

Samir Elhanbly1, Soheir Abdel-Gaber, Hanan Fathy

  • 1Department of Andrology, Mansoura University, Mansoura, Egypt.

Journal of Andrology
|October 13, 2004
PubMed
Summary

Cigarette smoking significantly contributes to erectile dysfunction (ED) primarily through impaired penile veno-occlusive mechanisms. Smokers show higher rates of abnormal nocturnal penile tumescence and rigidity (NPTR) and maintenance flow (MF) during pharmacocavernosometry.

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Area of Science:

  • Urology
  • Cardiovascular Science
  • Men's Health

Background:

  • Erectile dysfunction (ED) is a common condition with multifactorial causes.
  • Cigarette smoking is a recognized independent risk factor for ED.
  • The specific hemodynamic mechanisms by which smoking induces ED require further elucidation.

Purpose of the Study:

  • To investigate the hemodynamic mechanisms underlying smoking-induced erectile dysfunction.
  • To compare diagnostic parameters in current smokers versus nonsmokers with ED.
  • To identify which diagnostic parameters are most significantly affected by cigarette smoking.

Main Methods:

  • Standard ED evaluation including history, physical exam, and hormone levels.
  • Exclusion of patients with other ED risk factors or abnormal androgen profiles.

Related Experiment Videos

  • Nocturnal penile tumescence and rigidity (NPTR) monitoring, pharmacopenile duplex ultrasonography (PPDU), and redosing pharmacocavernosometry (RPC) in 109 ED patients (71 smokers, 38 nonsmokers).

    • Main Results:

    • Smokers were younger on average (44.3 vs. 51.2 years, P=.02).
    • Abnormal NPTR testing was more prevalent in smokers (86% vs. 55%, P=.02).
    • Abnormal maintenance flow (MF) during RPC was significantly higher in smokers (89% vs. 47%, P<.01).
    • Receiver operating characteristic (ROC) analysis indicated MF and penile base rigidity were strong predictors of smoking status.

    Conclusions:

    • Erectile dysfunction in smokers is predominantly of organic etiology.
    • Dysfunction of penile veno-occlusive mechanisms, indicated by abnormal MF, plays a substantial role in smoking-induced ED.
    • PPDU and RPC are valuable tools for assessing hemodynamic contributions to ED in smokers.