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Polyomaviruses and primary central nervous system lymphomas.

Jacinta M Murray1, Susan Morgello

  • 1Department of Pathology, Box 1143, Mount Sinai School of Medicine, New York, NY 11377, USA. jacinta.murray@mssm.edu

Neurology
|October 13, 2004
PubMed
Summary

This study found no link between polyomaviruses and primary CNS non-Hodgkin lymphoma (PCNSL) in HIV-1 infected or uninfected individuals. Polyomaviruses are unlikely to cause most PCNSL cases.

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Area of Science:

  • Neuro-oncology
  • Virology
  • Immunology

Background:

  • Primary CNS non-Hodgkin lymphoma (PCNSL) is a rare brain tumor.
  • The role of viral infections, including polyomaviruses, in PCNSL pathogenesis is not fully understood.
  • Human immunodeficiency virus type 1 (HIV-1) infection is a risk factor for PCNSL.

Purpose of the Study:

  • To investigate the association between polyomaviruses and PCNSL in both HIV-1 infected and uninfected individuals.
  • To determine if polyomaviruses play a role in the development of PCNSL.

Main Methods:

  • Immunohistochemical analysis of central nervous system (CNS) biopsies from 19 HIV-negative and 17 HIV-positive patients.
  • Polymerase Chain Reaction (PCR) analysis of CNS samples from 12 HIV-negative and 14 HIV-positive patients.

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Main Results:

  • All analyzed PCNSL samples from both HIV-positive and HIV-negative individuals were uniformly negative for polyomaviruses.
  • No evidence of polyomavirus presence was detected in the affected CNS tissues.

Conclusions:

  • Polyomaviruses are unlikely to be involved in the pathogenesis of the majority of primary CNS non-Hodgkin lymphoma cases.
  • The findings suggest that other etiological factors are more likely responsible for PCNSL development.