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Interactions between medicines and functional foods or dietary supplements
Noriaki Ohnishi1, Teruyoshi Yokoyama
1Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University Kyoto, Japan. ohnishi@mb.kyoto-phu.ac.jp
The Keio Journal of Medicine
|October 13, 2004
Summary
The use of dietary supplements alongside medications is rising. This study reviews potential pharmacokinetic and pharmacological interactions between supplements and drugs.
Area of Science:
- Pharmacology
- Nutritional Science
- Drug Interactions
Background:
- Growing global use of alternative and supplemental medicines.
- Increased co-administration of supplements with conventional drugs.
- Limited understanding of potential interactions.
Purpose of the Study:
- To review pharmacokinetic interactions between supplements and drugs.
- To review pharmacological interactions between supplements and drugs.
- To inform healthcare providers and patients about potential risks.
Main Methods:
- Literature review of pharmacokinetic studies.
- Literature review of pharmacological studies.
- Synthesis of interaction data.
Main Results:
- Identified potential for supplements to alter drug absorption, distribution, metabolism, and excretion.
- Documented instances of supplements affecting drug efficacy and toxicity.
- Highlighted variability in interaction mechanisms and clinical significance.
Conclusions:
- Supplement-drug interactions pose a significant clinical concern.
- Further research is needed to elucidate specific interaction pathways.
- Clinical vigilance and patient counseling are essential.