Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The target joint.

K Mulder1, A Llinás

  • 1Physiotherapy, Child Health, and Bleeding Disorders Clinic, Health Sciences Center, Winnipeg, Canada. kmulder@hsc.mb.ca

Haemophilia : the Official Journal of the World Federation of Hemophilia
|October 14, 2004
PubMed
Summary

Target joints in severe hemophilia (a bleeding disorder) often lead to permanent joint damage and osteoarthritis. Early, comprehensive treatment, including factor concentrate prophylaxis and physiotherapy, is crucial to prevent irreversible changes, especially in young patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Measurement of Neutrino Oscillation Parameters with 10 Years of Data from the NOvA Experiment.

Physical review letters·2026
Same author

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

Physical review letters·2024
Same author

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial.

ESMO open·2024
Same author

Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs.

Clinical rheumatology·2024
Same author

Measurement of the ν_{e}-Nucleus Charged-Current Double-Differential Cross Section at ⟨E_{ν}⟩=2.4  GeV Using NOvA.

Physical review letters·2023
Same author

<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography Parameters can Predict Long-Term Outcome Following Trimodality Treatment for Oesophageal Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022

Area of Science:

  • Orthopedics
  • Hematology
  • Pediatrics

Background:

  • Recurrent joint bleeding, known as target joints, is a primary complication in severe hemophilia.
  • This condition leads to progressive joint damage, loss of function, and eventually osteoarthritis.
  • Target joints pose significant challenges, particularly in young children due to susceptible articular cartilage.

Purpose of the Study:

  • To highlight the challenges associated with target joints in hemophilia patients.
  • To emphasize the need for early and comprehensive treatment strategies.
  • To discuss the role of synovectomy in managing persistent synovitis.

Main Methods:

  • Review of clinical manifestations and treatment outcomes for target joints in hemophilia.
  • Analysis of the impact of recurrent bleeding on joint structure and function.

Related Experiment Videos

  • Evaluation of conservative (prophylaxis, physiotherapy) and surgical (synovectomy) interventions.

    • Main Results:

    • Target joints result in irreversible joint damage, including loss of range of motion and muscle strength.
    • Early intervention with factor concentrate prophylaxis and physiotherapy can help resolve synovitis and prevent new bleeds.
    • Synovectomy is recommended for persistent synovitis, though challenging in pediatric cases.

    Conclusions:

    • Urgent and comprehensive treatment is vital to prevent permanent damage in target joints, especially in young hemophilia patients.
    • Factor concentrate prophylaxis and physiotherapy are key to managing synovitis and preventing bleeds.
    • Addressing target ankle joints in very young children requires tailored approaches due to cartilage susceptibility and treatment compliance issues.