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Updated: Aug 21, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Functional recovery after bleeding episodes in haemophilia
P De Kleijn1, M Gilbert, G Roosendaal
1Van Creveldkliniek, University Medical Centre Utrecht, Rudolf Magnus Institute of Neuroscience, Dept. Neurology and Neurosurgery, Section Rehabilitation Medicine, Universal Medical Center Uterecht, Uterecht, the Netherlands. p.dekleijn@azu.nl
Abstract:
Haemophilia is characterized by intra-articular and intramuscular bleeding episodes. Although much work has been carried out into post-bleeding mechanisms in both synovial joints and muscles, the picture is not yet clear. A firm post-bleeding rehabilitation protocol is of utmost importance for people with haemophilia. The use of the International Classification of Functioning Disability and Health reveals that information worldwide is on body level, whereas the goals of patients with haemophilia implicitly aim at optimal functional recovery. This interferes much more with activities and participation in society. The Functional Independence Score for Haemophilia and the Post-bleeding Protocol Based on Functional Milestones are examples of post-bleeding approaches that deal more with function. Two cases will emphasize the value of this approach.
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